Incorporating Electron-Transfer Functionality into Synthetic Metalloproteins from the Bottom-up
نویسندگان
چکیده
منابع مشابه
Incorporating electron-transfer functionality into synthetic metalloproteins from the bottom-up.
The alpha-helical coiled-coil motif serves as a robust scaffold for incorporating electron-transfer (ET) functionality into synthetic metalloproteins. These structures consist of a supercoiling of two or more aplha helices that are formed by the self-assembly of individual polypeptide chains whose sequences contain a repeating pattern of hydrophobic and hydrophilic residues. Early work from our...
متن کاملElectron-Transfer Functionality of Synthetic Coiled-Coil Metalloproteins
O campo emergente da engenharia molecular de metaloproteínas visa preparar proteínas artificiais, cujas propriedades podem imitar e talvez até mesmo melhorar várias características encontradas nas metaloenzimas naturais. Este artigo de revisão resume nossos esforços recentes na preparação de metaloproteínas sintéticas, construídas a partir de “coiled-coils” alfa-hélices, e na incorporação de gr...
متن کاملRegulation of Electron Transfer in Metalloproteins
The close functional interplay between the prosthetic group and the polypeptide chain in redox enzymes is the theme of this paper, and re— presents a natural extension of the well established regulation exerted by the protein mojety on the ligand binding properties of hemoglobins and other oxygen carriers. Two relevant examples are discussed: in the first one (azurin) the mole— cular mechanism ...
متن کاملA bottom-up characterization of transfer functions for synthetic biology designs: lessons from enzymology
Within the field of synthetic biology, a rational design of genetic parts should include a causal understanding of their input-output responses-the so-called transfer function-and how to tune them. However, a commonly adopted strategy is to fit data to Hill-shaped curves without considering the underlying molecular mechanisms. Here we provide a novel mathematical formalization that allows predi...
متن کاملIncorporating Deviation-Detection Functionality into the OLAP Paradigm
Although the integration of data mining and OLAP is obviously of great interest (if only due to the widespread availability of commercial-strength OLAP tools), relatively little progress has been made in this integration. The main goal of this paper is to contribute to this integration, by incorporating some data mining functionality (more precisely, deviation-detection functionality) into the ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Inorganic Chemistry
سال: 2006
ISSN: 0020-1669,1520-510X
DOI: 10.1021/ic060222j